Q School of Chemical and Biotechnology, SASTRA University, Thanjavur, Tamil Nadu, India r University of Florence, Florence, Italy H Department of Pharmaceutical Sciences, College of Pharmacy, Larkin Health Sciences Institute, Miami, FL, United States i Department of Urology, University of Miami, Miller School of Medicine, Miami, FL, United States j Miami Veterans Administration Medical Center, Miami, FL, United States k Department of Environmental Science, Dalhousie University, Canada ' Department of Microbiology and Immunology, Dalhousie University, Canada m Laboratory of Inflammatory Mediators, State University of West Paraná, UNIOESTE, Paraná, Brazil n Department ofBioMedical Sciences, School of Medicine, Creighton University, Omaha, NE, United StatesĠĝepartment of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC, United States p Huntsman Cancer Institute and Department of Internal Medicine, University of Utah, Salt Lake City, UT, United States HelferichE, Xujuan YangEĪ Sanus Biosciences, San Diego, CA, United States b Institute of Cancer Sciences, University of Glasgow, UKĬ Physics Department, School of Applied Mathematics and Physical Sciences, National Technical University of Athens, Athens, Greece d Department of Pathology, Wayne State Univeristy, Karmanos Cancer Center, USA e Department of Experimental and Clinical Medicine, University of Florence, Italyį Department of Biology, College of Science, United Arab Emirates University, AlAin, United Arab Emirates g Faculty ofScience, Cairo University, Cairo, Egypt Shantha Kumaraz, Somaira NowsheenC, Sulma I. Hofsetho, Luigi Ricciardiellox, Maria Rosa Ciriolov, Neetu Singhy, Richard L. Vasantha Rupasinghes, Hiromasa Fujiit, Kanya Honoki1, Kapil Mehtau, Katia Aquilanov, Leroy Lowew *, Lorne J. Stafforinip, Dipita Bhaktaq, Elena Niccolair, Gunjan Guhaq, H.P. Lokeshwarij, Brendan Gruekl, Carolina Panism, Chandra S. Azmid, Amedeo Amedeie, Amr Aminf g, Anupam Bishayeeh, Bal L. Seminars in Cancer Biology xxx (2015) xxx-xxxĪ multi-targeted approach to suppress tumor-promoting inflammation^Ībbas K. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. Georgakilas, Amedeo Amedei, Amr Amin, et al.Ĭancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. Abstract of research paper on Clinical medicine, author of scientific article - Abbas K.
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So, now I pay it forward by sharing the details here with you. I always thought recipes at craft cocktail bars like this one, the recipe was the secret sauce and therefore they wouldn't be so quick to share it. To my surprise, she did! Down to the 1/8 oz of ingredients, she had it written down for me on a napkin with the liquor brands and instructions included. I didn't hesitate to order another when the waitress returned and I facetiously asked the waitress to bring the recipe back with the next drink. The bitters and other ingredients just complimented it. The whiskey was the most present flavor, which is what you want. The cool temperature of this shaken cocktail held up surprisingly well through out the cocktail, although it's hard to say because it didn't last long.Īll of the flavors and portions of ingredients just worked perfectly in this cocktail. I had always made my own Old Fashioneds on the ball or cube of ice. First the drink mix had clearly been shaken with ice before being poured into the cocktail glass. This smoked cocktail now had my attention and I couldn't wait to take my first sip. First, the clean and refreshing smell of the orange peel hit me followed by the campfire-like smoke aroma, and finally the whiskey and sweetness finished it off. The smell of toasted wood and very slight wave of smoke still visible on the drink was very intriguing. The orange peel garnish was in the drink, not on the rim cocktail cherry rested on the bottom of the glass There were no ice cubes, sphere, or block The drink was served in traditional low ball whiskey cocktail glass I didn't have a good view of the bartender, but the staff behind the bar moved so quickly it would have been hard to keep up even if I did. This particular bar was known for their craft whiskey concoctions, so I didn't hesitate to place my order for an old fashioned. After a few cold beers at the game it was time for a change. I settled into a local bar one after noon after enjoying a Kansas City Royals baseball game. The best old fashioned I ever had stuck to the roots of the classic cocktail with just a few small, yet delightful changes, which changed my taste for the cocktail forever. An old fashioned can be whipped up in a matter of seconds with 3 simple ingredients of whiskey, bitters, and simple syrup, or it can be crafted carefully with many ingredient and garnish variations. I love the simplicity, complexity, aroma, flavor and even the history of it. The old fashioned cocktail is a cocktail as rich with history as flavor, and my personal favorite drink of choice. Template | replace: '.', '-' | handle = article Express the oil of an orange peel over the glass, then drop in.- | / Save up to % Save % Save up to Save Sale Sold out In stock.Fill an Old Fashioned glass with ice cubes, add the whisky or bourbon, and gently stir to combine.Add the sugar, bitters and water into a rocks glass, and stir until sugar is nearly dissolved.2 ounces Balvenie 12 year Old or Maker's Mark bourbon.1 dash sugar syrup or 1/2 teaspoon sugar.Wine World Recommends - Classic Old Fashioned Cocktail Recipe Old Fashioned Cocktail Ingredients When making classic cocktails like the Old Fashioned, Negroni or Tom Collins, it's important to ensure that you use a top quality spirit as this makes up 90% of the ingredients.įor a classic Old Fashioned recipe we recommend Balvenie 12 year Old for a classic whisky or Maker's Mark for a Bourbon option. This cocktail might appear simplistic but it's packed full of depth. The Old Fashioned is one of the world's oldest known cocktails that dates back to around 200 years ago. Humanmade works with local manufacturing partners to create custom training materials to address and fill their current hiring needs. With the help of advisors and manufacturing partners, we provide individuals with industry-standard skills and knowledge for entry-level jobs. MANUFACTURING PARTNERS & INDUSTRY ADVISORS By mastering advanced manufacturing skills through comprehensive instruction and mentoring from our expert staff, Humanmade can ensure you will have a safe, meaningful, and rewarding experience. With brand new, industry-standard, rapid prototyping, manufacturing tools, and software, Humanmade provides access to cutting-edge facilities, training, and experiences. From Workforce Development training programs to after school STEAM programs, Humanmade guides individuals in our community to become the next generation of inventors, designers, and makers by providing access to the best training, tools, and facilities.Īnyone can signup and join Humanmade! Our top-notch facility is available and accessible to anyone in our community who has a desire to learn and grow. By offering multiple types of training, from entry-level to advanced, our mission is to provide individuals with life-changing skills. Located in the heart of San Francisco's Design District, Humanmade brings an all-new "learn-design-make-manufacture" model to the industry. Humanmade is an Advanced Manufacturing Training Center with an open-access Design, Fabrication, and Prototyping Facility that empowers individuals with the skills to create a better future. In emphasizing cereal's convenience and nutritional value, Kellogg's helped persuade U.S. LaMothe to improve, which primarily involved approaching the demographic of 80 million baby boomers rather than marketing children-oriented cereals. Such comments stimulated Kellogg chairman William E. A prominent Wall Street analyst called it "a fine company that's past its prime" and the cereal market was being regarded as "mature". After underspending its competition in marketing and product development, Kellogg's US market share hit a low 36.7% in 1983. Smith's Pies, Eggo, and Pure Packed Foods however, it was later criticized for not diversifying further like General Mills and Quaker Oats were. From 1969 to 1977, Kellogg's acquired various small businesses including Salada Foods, Fearn International, Mrs. įrom 1969 to 1970, the slogan “Kellogg's puts more into your day” was used on Sunday morning TV shows. This practice remained until World War II, and continued briefly after the war, although some departments and factories remained locked into 30-hour work weeks until 1980. Kellogg stated that he did this so that an additional shift of workers would be employed in an effort to support people through the depression era. In 1931, the Kellogg Company announced that most of its factories would shift towards 30-hour work weeks, from the usual 40. The resulting legal battle, which included a trial that lasted an entire month, ended in December 1920 when the Michigan Supreme Court ruled in Will’s favor. John, who resented his brother’s success, filed suit against Will's company in 1906 for the right to use the family name. īy 1909, Will's company was producing 120,000 cases of Corn Flakes a day. Ĭonvincing his brother to relinquish rights to the product, Will's company produced and marketed the hugely successful Kellogg's Toasted Corn Flakes and was renamed the Kellogg Toasted Corn Flake Company in 1909, taking on the current name of the Kellogg Company in 1922. Kellogg had the new plant in full operation six months after the fire. On July 4, 1907, a fire destroyed the main factory building. launched the Battle Creek Toasted Corn Flake Company on February 19, 1906. As a result, the brothers fell out, and W. John Harvey forbade his brother Will from distributing cereal beyond his consumers. Soon the flaked wheat was being packaged to meet hundreds of mail-order requests from guests after they left the Sanitarium. Kellogg persuaded his brother to serve the food in flake form. Rather than throwing it out the next morning, he sent it through the rollers and was surprised to obtain delicate flakes, which could then be baked. It is generally agreed that upon being called out one night, John Kellogg left a batch of wheat-berry dough behind. There is considerable disagreement over who was involved in the discovery, and the role that they played. The development of the flaked cereal in 1894 has been variously described by those involved: Ella Eaton Kellogg, John Harvey Kellogg, his younger brother Will Keith Kellogg, and other family members. The Kelloggs are best known for the invention of the famous breakfast cereal corn flakes. Kellogg assisted his brother in research aimed at improving the vegetarian diet of the Battle Creek Sanitarium's patients, especially in the search for wheat-based granola. This is where corn flakes were created and led to the eventual formation of the Kellogg Company.įor years, W. In 1876, John Harvey Kellogg became the superintendent of the Battle Creek Sanitarium (originally the Western Health Reform Institute founded by Ellen White) and his brother, W. corn flakes package (1906), later to become the Kellogg Food Company in 1908 First Battle Creek Toasted Corn Flake Co. Sara, Valentine's Faye, and Young L'Arachel demoted to 9.0Īscended Celica, Valentian Est, and Ymir added to 9.0 Shez (M), Monica, Ascended Hilda, Shez (F), and Holst added to 9.0įlame Tribe Lyn and Flame Tribe Tana added to 9.5įlame Tribe Múspell and Flame Tribe Mordecai added to 9.0īrave Byleth (F), Brave Seliph, Brave Tiki (Adult), and Brave Chrom added to 9.5īrave Marianne and Spring Myrrh demoted to 9.0 Halloween Duma and Halloween Corrin (F) added to 9.5 Who Should You Pull From Divine Harvest? Recent Free Units Halloween Nils Since Marth and Alear are outside when talking, this means that the area at the back is semi-outdoors.Recent FEH Character Ratings Ratings for New Heroes Divine Harvest Halloween Corrin (F) When Alear is talking, you can see the reception desk (from the reveal trailer) behind him. Update: Oh, there is one more thing I just noticed. Or perhaps the ring is more like a window or doorway and Marth can somehow travel between Elyos and Archanea. Perhaps Marth is only semi-conscious or something? Like in an idle or sleeping state himself, but still aware of what’s happening?Īlso, what if Marth needed to save Archanea again during those 1000 years? Is he stuck inside his ring? Oh, I guess time could flow differently in Elyos. Unless this is unique to Marth or something.īesides that, I hope Marth has been keeping busy during those 1000 years! I get he’s a nice guy, but just watching somebody sawing logs for a millenium must be pretty dang dull. I think this occurs in the same area as this screenshot from the reveal trailer–basically, back at your base.Īpparently, Marth has been watching over Alear ever since they were asleep, so for around 1000 years? This has various implications namely, the Emblems don’t just pop out of nowhere when they’re first summoned. Or perhaps it’s related to Speed? In the new footage, Alear cannot double attack.įinally, here’s a conversation between Marth and Alear: The only thing that comes to mind is the weapon triangle Alear has a disadvantage in the new footage, whereas they had an advantage previously. I don’t think it’s like Dual Strikes from FE Awakening that have a random chance of triggering, because you can see (presumably) Marth’s damage number (6) on the right screenshot. However, Marth doesn’t appear to fight in the new footage, whereas he seems to fight in the old footage (that said, the footage cut off before we saw Marth attack the foe). In both cases, Marth’s Perceptive (aka Nihil) skill kicks in at the start of battle. Left is the footage from today’s post right is from the reveal trailer. Pressing the + button will trigger Engage prior to the fight. Despite Marth being equipped, Marth doesn’t seem to actively contribute in combat. Engage Count probably refers to the countdown before an Engaged character reverts.ĭuring the battle forecast, we see that Alear will deal 9 damage while the foe will deal 10. It’s said to be “for Divine Dragons only” and grants Engage Count +1 if the wielder lands the finishing blow on an enemy. Libération is a D rank sword it seems (that or it’s Alear’s sword rank that’s D). Presumably Alear acts as the convoy, so he/she can access it whenever, while other characters must move next to Alear to do so.Īlear’s weapons/items include Libération, an Iron Sword and Vulnerary. The first option is Engage, which combines Alear and Marth. When Alear moves towards the enemy, we see the actions menu, which wasn’t shown in the trailer. (Also, Framme is still to the far left she’s just blocked by Alear’s portrait right now.) The only difference is that Alear is now equipped with Marth–and receives a stat boost because of this. On the left is the footage from today’s Twitter post on the right is from the reveal trailer. This appears to be the same verdant kingdom map that appeared in the reveal trailer. He’s always been an athletic freak, able to finish with power or finesses, with either hand. Meanwhile he led the NBA in steals, and once again cemented himself as the best chasedown block artist in the League not named LeBron James. His scoring jumped to just over 27 ppg in the playoffs, including a 42-point, 8-assist, 4-steal, 2-block performance to close out the Hawks in the first round. He posted career-highs in Win Shares, points (22.9) and assists (10.5) in 2016-17, shot his best-ever field goal percentage and true shooting percentage, and was the only player besides James Harden and Russell Westbrook to post 20+ ppg and 10+ apg. Wall carried the Wizards to the brink of an Eastern Conference Finals appearance (right up until Kelly Olynyk turned into Larry Bird) on the strength of the best numbers of his seven-year career. There are two types of people in the world: People who know that statement to be true, and people who simply refuse to acknowledge it. It wouldn’t be possible without all the money he has made on the court, either.John Wall will be a top-10 player in the NBA this season. No matter how large Wall’s stake is, it’s probably pretty cool to own part of a professional basketball team. “… I know there is plenty I can contribute to the growth of the franchise and I’m especially looking forward to getting down to South East Melbourne and meeting the team and the fans when travel restrictions are lifted.” “I’m so excited to be coming on board with the Phoenix,” Wall said, according to ESPN. He is not the only current or former NBA player in the ownership group, either, as Josh Childress, Zach Randolph, Al Harrington, and Dante Exum are all involved in it as well. RELATED: Pau Gasol Has a Massive Net Worth After Winning Championships With Kobe Bryant on the LakersĪccording to ESPN, in November 2020, John Wall joined the ownership group for the South East Melbourne Phoenix of Australia’s National Basketball League, as he bought a stake in the team. is the latest NBA player to become a part-owner of an team, buying a stake in the #NBL21 - NBA Australia November 24, 2020 He owns part of the South East Melbourne Phoenix in the NBL That money has also ultimately led to him owning part of a professional basketball team. Wall has certainly had a lot of success in the NBA, which has helped him make plenty of money. The Washington Wizards have since traded John Wall to the Houston Rockets, and he has continued to produce at a high level in Houston.įor his career, through 20 games in the 2020-21 season, Wall is averaging 19 points per game, 9.1 assists, and 4.3 rebounds. Wall, though, only appeared in 41 games in 2017-18, and then 32 in 2018-19 before missing the entire season due to injury in 2019-20. His play even helped him earn All-NBA honors that season, too. He averaged a career-high 23.1 points per game that year to go with career-highs in assists with 10.7 and steals with two per game. Wall’s best season during that five-year stretch, though, came in 2016-17. He ultimately earned his first of five consecutive All-Star selections that year, as he averaged 19.3 points per game, 8.8 assists, and 4.1 rebounds. In 2013-14, though, Wall officially became one of the best players in the NBA. After averaging a little over 16 points and around eight assists in his first two seasons, Wall’s scoring numbers jumped up to 18.5 in his third season. He had quite a bit of success in his first three seasons in the league, too. 1 overall pick in the 2010 NBA draft after he had become a star for the Kentucky Wildcats in college. The Washington Wizards selected John Wall with the No. RELATED: LeBron James’ Upcoming $1 Billion Achievement Is a Feat Michael Jordan Never Even Reached 3.3 a duality between multipath-intensity function Λ ( τ ) and Doppler power spectrum Λ ( ν ) is shown, which means that the two functions exhibit similar behavior across time domain and frequency domain. The coherence distance is inversely proportional to the angle spread D c ∝ 1 / θ R M S. The space-selective fading is characterized by the coherence distance D c which is the spatial separation for which the autocorrelation coefficient of the spatial fading reduces to 0.7. The angle spread causes space-selective fading, which manifests itself as variation of signal amplitude according to the location of antennas. The significance of delay spread depends on the time-width of the signal relative to that of the channel hence a quantitative characterization of the severances of channel delay-spread is necessary. This phenomenon is referred to as delay spread. Consequently, when a “narrow” pulse is transmitted over a multipath propagation channel, distorted replicas of the transmitted pulse arrive at the receiver at various different times, making the received signal “wider” in time than the transmitted signal. In a multipath propagation environment the received signal consists of a large number of components having different delays. The small-scale variations include signal fading, delay-spread and Doppler-spread, which we believe contribute to transmission errors in a digital environment. Our research focuses on mitigating the effects of the small-scale variations using digital signal processing techniques. These variations are referred to as large-scale variations because they are obtained from measurement data taken at various locations in a large area. In the second step, variations of the large-scale statistics are determined from measurements taken in different multipath environments. The statistics thus collected are referred to as small-scale variations, because they are usually obtained from measurement data obtained at various locations in a small area. In the first step, it is assumed that the multipath environment is fixed, and variations of the received signal are measured for the given multipath environment. Since the properties of the received signal are clearly a strong function of the multipath environment, statistical characterization of the received signal is often done in a two-step process. The statistics of this random process can be collected from extensive field measurements in selected operation environments. One common approach is to treat the received signal as a spatial-temporal random process. Multipath propagation is a rather complicated phenomenon that is cumbersome to characterize. The receiver antenna output is the sum of the multiple signal copies weighted by the antenna gain pattern. Since the different versions of the signal propagate through different paths, they will in general have different attenuation, phase shifts, time delays, and angles of arrival. The receiver antenna will therefore receive multiple copies of the transmitted signal. The much stronger proton signals allow the coil to be less optimized for these signals and still produce adequate images. Often, dual-tuned coils are used so that proton images can be obtained using the same coil. The coil should also be uniformly sensitive throughout the VOL Surface coils are often employed because the coil can be positioned closer to the signal-generating nuclei, and because the localized reception profile means that less noise will be collected from regions of the object (usually the dominant source of noise) remote from the coil. The coil should be tuned to the object to maximize the efficiency of signal collection. Because of the acute SNR limitations to MRS measurements, additional care needs to be taken with respect to coil efficiency and other areas of potential signal loss. Measurement at different resonance frequencies typically means that different RF transmitter and receiver antenna coils must be designed and used. Sanders, in Functional Brain Imaging, 1995 Coils. So does Flintobox deliver the goods? Pun intended. And each of this box has a different theme, so your kid could be doing a mini science experiment one month and playing with air balloons the next. From infants to toddlers to kids to pre-adults, they have something for kids of different age groups.Įach month, a activity box packed with goodies is delivered right at your doorstep. Turned out it was Flintobox, and I was happy and excited to give it a go.įor those of you who don’t know much about Flintobox, they are a chennai-based startup delivering subscription boxes for kids. I had Pari pick a chit from a bowl and decide what kit he got to play with first. I was excited about the whole idea and wanted to try out one.įollowing through with that discussion, I decided to find out more about activity boxes for kids in general and the companies selling them.Ī quick Google search opened up a whole new world of the best activity boxes for kids in India. From Flintobox to Magic Crate, there were several companies delivering monthly subscription activity boxes, and I didn’t know which to pick. He talked about how these activities are both educative and fun at the same time, and how they help to make kids like Pari learn new things while having fun. One day, my brother and I were discussing the different activity boxes for kits. In whatever time I get to be with my little son, I find it tough to to keep him engaged meaningfully, and off the TV and mobile phone. To scale up - Durairaj says Flintobox needs money for technology, product development and marketing - the company plans to raise around Rs 1.5 crore in coming weeks, which it expects to last about 15 months.Flintobox Kids Activity Box Review As a working mom, I have always been looking for better ways to engage my 4 year old son, Pari.Ī bundle of energy, Pari is always on to something whether it be playing with his set of Marvel superhero toys, identifying different species of dinosaurs or catching up with latest videos on his favorite YouTube channels etc. It has come to its current size with just Rs 15 lakh in funding from GSF Accelerator, part of Global Super Angel Forum, an early-stage funding group that funded Bangalore-based Little Eye Labs that Facebook bought earlier this year. It has also started supplying boxes branded 'Inbox' to a toys retailer in Singapore and has enquiries from Tanzania and Nigeria.įlintobox's costs are at about Rs 5 lakh a month and it expects to break even when it ships 1,500 boxes a month. The company has not spent "anything on marketing" and hasn't pushed sales in Delhi and Mumbai, two of India's biggest markets for toys. "We started with 80 boxes (a month) and have a standing order for 300 a month from next," he says. He points to appetite on Flipkart, which Flintobox started retailing boxes on in February. Revenues are about Rs 3.5 lakh a month and Durairaj expects that to climb to Rs 50 lakh a month by March 2015. Some 450 of them are on subscriptions, typically of three months, and 150 are single-box sales. Gandhi worked with the likes of Sun Microsystems, Oracle and July Systems - his wife was Durairaj's colleague at TCS - before making the leap into a business he knew nothing about but lived a parent's urgent need.Īadhav and Mathew are among 600 kids who rip open their Flintoboxes every month. In Tamil, pambaram is a top and pandi refers to a hopscotch kind of game. I tried to introduce him to pambaram or pandi but the peer pressure was too much for him," says Gandhi, 33. "I used to play with him but found him not engaged. The idea of Flintobox - the name comes from the company's mascot, an orange octopus with eight legs (yes, it stands) - came from Co-founder Vijaybabu Gandhi's efforts in keeping his son Aadhav's curiosity piqued. After that, it is like plastering and painting a building," says Durairaj, who in past avatars has worked for Tata Consultancy Services in product management and in an M&A role at Samsung, besides a venture fund in Boston after an MBA at Dartmouth. "The foundation of a child's learning is laid before eight years. The boxes have toys themed around topics like wildlife, vegetables, colouring, outer space, numbers and others, all aimed at 12 development needs in children. COOL QUOTIENT: A box of fun learning toys delivered every month MacOS Big Sur 11.5 provides important security updates and is recommended for all users.Įnables the ability to install third-party applications:Ĭreating a bootable USB flash drive. Smart cards may not work when logging in on Macs equipped with an M1 chip.Music might not update the play count and last play date in the library.This release also fixes the following issues: The Podcast Library panel allows you to choose whether to view all podcasts or only those you follow.MacOS Big Sur 11.5 includes the following improvements for the Mac: MacOS Big Sur has stopped supporting the following Apple computer models: MacOS 10.16 DP1 Big Sur supports the following models: Apple designers have redrawn all standard applications in the new operating system. Overall, the new macOS is not only simpler and more minimalistic, it is now similar to iOS 14 (in fact, more on iPadOS 14). And learn even more about ways to protect your personal data Pay tribute to Safari's biggest update yet. Enjoy a striking design that makes your Mac experience even easier. MacOS Big Sur takes Mac to new heights of performance and visual aesthetics. The combination of Big Sur and M1 opens new horizons for productivity and efficiency on Mac and expands the possibilities of applications - all in the familiar macOS interface that users love so much. MacOS Big Sur is deeply integrated with the Apple M1 chip in the new 13-inch MacBook Pro, as well as the new MacBook Air and Mac mini. Big Sur has a great new interface and many improvements to the main applications, including Safari, Messages and Maps, as well as unique new privacy protection features. MacOS Big Sur - the latest version of the leading desktop operating system - is already available for Mac users as a free update. Upgrades from earlier versions require up to 34 GB of free disk space.Some features require a compatible Internet service provider fees may apply.Some features require an Apple ID conditions are required.!!! 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